Combating bacterial biofilms: agents and mechanisms of action

Biofilm refers to the complex, sessile communities of microbes found either attached to a surface or buried firmly in an extracellular matrix as aggregates. The biofilm matrix surrounding bacteria makes them tolerant to harsh conditions and resistant to antibacterial treatments. Moreover, the biofilms are responsible for causing a broad range of chronic diseases and due to the emergence of antibiotic resistance in bacteria it has really become difficult to treat them with efficacy. Furthermore, the antibiotics available till date are ineffective for treating these biofilm related infections due to their higher values of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC), which may result in in-vivo toxicity. Hence, it is critically important to design or screen anti-biofilm molecules that can effectively minimize and eradicate biofilm related infections. In the present article, we have highlighted the mechanism of biofilm formation with reference to different models and various methods used for biofilm detection. A major focus has been put on various anti-biofilm molecules discovered or tested till date which may include herbal active compounds, chelating agents, peptide antibiotics, lantibiotics and synthetic chemical compounds along with their structures, mechanism of action and their respective MICs, MBCs, minimum biofilm inhibitory concentrations (MBICs) as well as the half maximal inhibitory concentration (IC50) values available in the literature so far. Different mode of action of anti biofilm molecules addressed here are inhibition via interference in the quorum sensing pathways, adhesion mechanism, disruption of extracellular DNA, protein, lipopolysaccharides, exopolysaccharides and secondary messengers involved in various signaling pathways. From this study, we conclude that the molecules considered here might be used to treat biofilm-associated infections after significant structural modifications, thereby investigating its effective delivery in the host. It should also be ensured that minimum effective concentration of these molecules must be capable of eradicating biofilm infections with maximum potency without posing any adverse side effects on the host.
REFERENCE:
Roy, Ranita et al. “Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action.” Virulence vol. 9,1 (2018): 522-554. doi:10.1080/21505594.2017.1313372

-----------------------------------------------------------
Sigue este Blog en Facebook y Twitter
-----------------------------------------------------------

Principles of Laboratory Biosafety e-Learning Course

This portal is your entry into the biosafety learning and knowledge services offered by the Centre for Biosecurity of the Public Health Agency of Canada and the Office of Biohazard Containment and Safety of the Canadian Food Inspection Agency. Here you will find tools for you to promote safer biosafety practices in your facility.

Whether you are a biosafety professional, a containment facility user or manager, an engineer, architect or otherwise involved in designing or managing containment facilities, or even if you simply have an interest in biosafety, there are materials here for you. The materials on this portal are provided to be used as part of a biosafety training program specific to your facility. Working together we can promote the importance of biosafety and its application in Canadian facilities.

The portal currently contains a variety of courses and resources, including:

Principles of Laboratory Biosafety e-Learning Course

This modular course has been developed by the Public Health Agency of Canada and the Canadian Food Inspection Agency to help strengthen biosafety and biosecurity principles.

Instructional videos on biosafety which can be viewed for free online:

• Biosafety 101
• Containment Level 1 Laboratory: Operational Practices
• Containment Level 2 Laboratory: Operational Practices
• Containment Level 3 Laboratories: Operational Practices

https://training-formation.phac-aspc.gc.ca/course/index.php?categoryid=2

-----------------------------------------------------------
Sigue este Blog en Facebook y Twitter
-----------------------------------------------------------

Canadian Biosafety HANDBOOK, 2nd Ed.

The Government of Canada's Canadian Biosafety Handbook (CBH), 2nd Edition, 2016, is a national guidance document for the safe handling and storing of human and terrestrial animal pathogens and toxins in Canada. It is a companion document to the Canadian Biosafety Standard (CBS), 2nd Edition, 2015 in which the physical containment, operational practice, and performance and verification testing requirements are set out to ensure the safe handling and storing of human and terrestrial animal pathogens and toxins. Activities in Canada involving human and animal pathogens and toxins are regulated by the Public Health Agency of Canada (PHAC) and the Canadian Food Inspection Agency (CFIA) in accordance with the Human Pathogens and Toxins Act, Human Pathogens and Toxins Regulations, Health of Animals Act, and Health of Animals Regulations. The CBH provides the core information and guidance on how to achieve the biosafety and biosecurity requirements specified in the CBS. The CBH systematically addresses the concepts required for the development and maintenance of a comprehensive risk-based biosafety management program.
REFERENCE:

DOWNLOAD

© Her Majesty the Queen in Right of Canada, as represented by the
Minister of Health and the Minister of Agriculture and Agri-Food, 2016
https://www.canada.ca/en/public-health/services/canadian-biosafety-standards-guidelines/handbook-second-edition.html#pr
Publication date: March 2016
This publication may be reproduced for personal or internal use only without permission
provided the source is fully acknowledged.
Print Cat.: HP45-9/2015E PDF Cat.: HP45-9/2015E-PDF
ISBN: 978-1-100-25773-0 ISBN: 978-1-100-25774-7
Publication Number: 140469

The CBS Biosafety App v2.0 is currently available as a free download for the following devices:

• Android (including phones and tablets)
• Apple (including iPhones and iPads)
• Online version

-----------------------------------------------------------
Sigue este Blog en Facebook y Twitter
-----------------------------------------------------------

Canadian Biosafety STANDARD, 2nd Ed.

The Government of Canada's Canadian Biosafety Standard (CBS), 2nd Edition, 2015, is a harmonized national standard for the handling or storing of human and terrestrial animal pathogens and toxins in Canada. Activities in Canada involving human and animal pathogens and toxins are regulated by the Public Health Agency of Canada (PHAC) and the Canadian Food Inspection Agency (CFIA) in accordance with the Human Pathogens and Toxins Act (HPTA), the Human Pathogens and Toxins Regulations (HPTR), the Health of Animals Act, and the Health of Animals Regulations.
The CBS sets out the physical containment, operational practice, and performance and verification testing requirements for the safe handling or storing of human and terrestrial animal pathogens and toxins. The CBS updates many requirements to be more risk-, evidence-, and performance-based, as well as incorporating new information in the field of biocontainment engineering. In addition, the CBS includes several new requirements and information to support the full implementation of the HPTA and the HPTR. On December 1st, 2015, the HPTR comes into force and the CBS will come into effect and supersede the CBSG. The CBS will be used by the PHAC and the CFIA to verify the ongoing compliance of regulated facilities with the applicable legislation. This will support licence applications, renewals, animal pathogen import permit applications, and, where applicable, the facility certification (and recertification) of containment zones.
It has a companion document: Canadian Biosafety Handbook, 2nd. Ed. 
REFERENCE:

DOWNLOAD

© Her Majesty the Queen in Right of Canada, as represented by the Minister of Health
and the Minister of Agriculture and Agri-Food, 2015
https://www.canada.ca/en/public-health/services/canadian-biosafety-standards-guidelines/second-edition.html
Publication date: March 2015
This publication may be reproduced for personal or internal use only without permission
provided the source is fully acknowledged.
Print Cat.: HP45-7/2015E PDF Cat.: HP45-7/2015E-PDF
ISBN: 978-1-100-25771-6 ISBN: 978-1-100-25772-3
Publication Number: 140467

The CBS Biosafety App v2.0 is currently available as a free download for the following devices:

• Android (including phones and tablets)
• Apple (including iPhones and iPads)
• Online version

-----------------------------------------------------------
Sigue este Blog en Facebook y Twitter
-----------------------------------------------------------

Quaternary Ammonium Leucine-Based Surfactants

Quaternary ammonium amphiphiles are a class of compounds with a wide range of commercial and industrial uses. In the pharmaceutical field, the most common quaternary ammonium surfactant is benzalkonium chloride (BAC), which is employed as a preservative in several topical formulations for ocular, skin, or nasal application. Despite the broad antimicrobial activity against Gram-positive and Gram-negative bacteria, as well as fungi and small enveloped viruses, safety concerns regarding its irritant and cytotoxic effect on epithelial cells still remain. In this work, quaternary ammonium derivatives of leucine esters (C10, C12 and C14) were synthesised as BAC analogues. These cationic surfactants were characterised in terms of critical micelle concentration (CMC, by tensiometry), cytotoxicity (MTS and LDH assays on the Caco-2 and Calu-3 cell lines) and antimicrobial activity on the bacterial species Staphylococcus aureus and Enterococcus faecalis among the Gram-positives, Escherichia coli and Pseudomonas aeruginosa among the Gram-negatives and the yeast Candida albicans. They showed satisfactory surface-active properties, and a cytotoxic effect that was dependent on the length of the hydrophobic chain. Lower minimum inhibiting concentration (MIC) values were calculated for C14-derivatives, which were comparable to those calculated for BAC toward Gram-positive bacteria and slightly higher for Gram-negative bacteria and C. albicans. Thus, the synthesised leucine-based quaternary ammonium cationic surfactants can potentially find application as promising surface-active compounds with antimicrobial activity.
REFERENCE:
Perinelli DR, Petrelli D, Vitali LA, et al. Quaternary Ammonium Leucine-Based Surfactants: The Effect of a Benzyl Group on Physicochemical Properties and Antimicrobial Activity. Pharmaceutics. 2019;11(6):287. Published 2019 Jun 19. doi:10.3390/pharmaceutics11060287

-----------------------------------------------------------
Sigue este Blog en Facebook y Twitter
-----------------------------------------------------------

2020 CDC Yellow book: Traveler's health

ISBN:
978-0-19-092893-3  paperback
978-0-19-006597-3  hardback

CDC's Yellow Book (Health Information for International Travel) is published every two years as a resource for health professionals providing care to international travelers. The fully revised and updated CDC Yellow Book 2020 compiles the US government’s most current travel health guidelines, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2020 Yellow Book includes important travel medicine updates:

• Recommendations for providing travel health care remotely via telemedicine
• Discussion of legal issues facing clinicians providing travel health care
• Cutting-edge rapid diagnostic tests for infectious diseases
• Introduction of new FDA-approved antimalarial drugs
• Road traffic safety advice for travelers
• Recommendations for treating infectious diseases in the face of increasing antimicrobial resistance

CHAPTERS:

1. Introduction
2. Preparing International Travelers
3. Environmental Hazards & Other Noninfectious Health Risks
4. Travel-Related Infectious Diseases
5. Travelers with Additional Considerations
6. Health Care Abroad
7. Family Travel
8. Travel by Air, Land & Sea
9. Travel for Work & Other Reasons
10. Popular Itineraries
11. Posttravel Evaluation
12. Appendices

REFERENCES:

https://wwwnc.cdc.gov/travel/yellowbook/2020/table-of-contents
https://wwwnc.cdc.gov/travel/yellowbook/2020/updates

-----------------------------------------------------------
Sigue este Blog en Facebook y Twitter
-----------------------------------------------------------

100 Years of Respiratory Protection History

In 1919, the U.S. Bureau of Mines (USBM) initiated the first respirator certification program. Several months later, on January 15, 1920, this federal body certified the first respirator. To recognize the important milestones of the past 100 years, this webpage documents a general historical overview of respiratory protection research and the evolution of the certification program as undertaken by the U.S. federal government.
Read the full history at:
https://www.cdc.gov/niosh/npptl/Respiratory-Protection-history.html

-----------------------------------------------------------
Sigue este Blog en Facebook y Twitter
-----------------------------------------------------------

#LIBRO: Entendiendo la economía de las amenazas microbianas (INGLÉS)

Publication Info

168 pages | 6 x 9 
ISBNs: 

• Paperback: 978-0-309-48302-5
• Ebook: 978-0-309-48305-6

DOI: https://doi.org/10.17226/25224 

Las amenazas microbianas, incluidas las enfermedades infecciosas endémicas y emergentes y la resistencia a los antimicrobianos, pueden causar no solo consecuencias sustanciales para la salud, sino también una enorme interrupción de la actividad económica en todo el mundo. Si bien los avances científicos sin duda han fortalecido nuestra capacidad para responder y mitigar la mortalidad de las amenazas de enfermedades infecciosas, los eventos ocurridos en las últimas dos décadas han ilustrado nuestra continua vulnerabilidad a las consecuencias económicas de estas amenazas.
Para evaluar la comprensión actual de la interacción de las amenazas de enfermedades infecciosas con la actividad económica y sugerir nuevas áreas potenciales de investigación, las Academias Nacionales de Ciencias, Ingeniería y Medicina planearon un taller público de 1.5 días sobre la comprensión de la economía de las amenazas microbianas. Este taller se basó en el trabajo previo del Foro sobre Amenazas Microbianas y tuvo como objetivo ayudar a transformar el conocimiento actual en acción inmediata. Esta publicación resume las presentaciones y discusiones del taller.

REFERENCE:
National Academies of Sciences, Engineering, and Medicine. 2018. Understanding the Economics of Microbial Threats: Proceedings of a Workshop. Washington, DC: The National Academies Press. https://doi.org/10.17226/25224.

-----------------------------------------------------------
Sigue este Blog en Facebook y Twitter
-----------------------------------------------------------

17 casos confirmados de #Sarampión en #México 2019Sep11

DESCARGAR PDF

REFERENCIA:
Página Web: https://www.gob.mx/salud/documentos/casos-confirmados-por-sarampion-2019.
Dirección General de Epidemiología, Secretaría de Salud
Fecha de publicación: 11 de septiembre de 2019
SARAMPIÓN, MÉXICO: Casos Confirmados 2019

-----------------------------------------------------------
Sigue este Blog en Facebook y Twitter
-----------------------------------------------------------

#VIDEOS: Good Microbiological Practices and Procedures #GMPP, @WHO (3/3)

Biological safety cabinets (BSC)

1. Introduction: Biological safety cabinets (BSCs) are primary containment devices designed to protect laboratory workers and the surrounding environment from potential exposure to infectious agents. This video provides an overview of the type of activities that should be conducted within BSCs and how BSCs work as well as different types of BSCs available, followed by installation recommendations to ensure proper containment.

2. Preparatory steps: Prior to working with infectious material inside BSCs, there are a few important steps to take to make sure that work will be done safely and the cabinet is functioning correctly, including proper maintenance, disinfection and organization of workflow.

3. Best practices for safe usage: It is always important to follow best practices while working in BSC to help maintain adequate airflow within the cabinet, leading to prevention of exposures and release of pathogens. Work from ‘clean’ to ‘dirty’ and dispose of contaminated waste inside the cabinet and complete the work by decontamination.

4: Incident management: In the event of an emergency or cabinet malfunction, operators must be prepared to quickly react in a safe and secure manner. This video highlights the importance of a facility’s Standard Operating Procedures and spill control. It also provides guidance on a loss of cabinet power or any other emergencies.

REFERENCE:

Biosafety video series. who.int/ihr/publications/biosafety-video-series/en/

-----------------------------------------------------------
Sigue este Blog en Facebook y Twitter
-----------------------------------------------------------

#VIDEOS: Good Microbiological Practices and Procedures #GMPP, @WHO (2/3)

4. Surface decontamination: In the laboratory, there are many surfaces and pieces of equipment that can become contaminated by biological agents or other hazardous materials. Decontamination is required to reduce the risk of infection or harm. Disinfectants, which are chemicals which can kill or neutralise biological agents, are often used for surface decontamination. The choice of disinfectant, their concentration and contact time will all vary depending on the biological agents you are handling.

5: Autoclaves: Of all the methods available to decontaminate laboratory waste, autoclaving is one of the easiest and most effective. Autoclaving combines heat, steam and high pressure to kill biological agents. It is important to note that some biological agents are more robust than others, for example bacterial spores and prions. Pre-treatment with disinfectant, increased temperature, pressure, and contact time may be required to neutralise such agents.


6. Workflow: The term “Workflow” is used to describe how the laboratory is set up into different work areas, and the procedures and systems that enable the people in the facility to carry out their work efficiently and safely. It is important that the workflow at the facility reduces the likelihood of staff being exposed to biological agents; biological agents being released outside the laboratory; and cross contamination.


7. Transport. There will always be a need to transport biological material from one place to another. This could be within a single laboratory, between laboratories in the same facility, or between facilities in different locations. Safe methods and procedures must be in place to prevent any release and risk of infection to the individuals transporting the materials or anyone else the materials might come into contact with.

-----------------------------------------------------------

Sigue este Blog en Facebook y Twitter
-----------------------------------------------------------

#VIDEOS: Good Microbiological Practices and Procedures #GMPP, @WHO (1/3)

1. Personal protective equipment (PPE): Personal Protective Equipment, or PPE, is the clothing and equipment that forms the last line of defence between you and harmful materials in the laboratory environment. It’s essential that you know what you should be wearing, when you should be wearing it, and how it should be stored, cleaned, maintained and disposed of.

2. Pipettes: Work in a microbiology laboratory involves a lot of handling and transferring of liquids in small, precise volumes. This is mainly done using pipettes. It is important to know how to use them properly so that you can make accurate volume transfers,reduce the numbers of aerosols generated and prevent contamination of the pipette and subsequent cross contamination of samples.

3. Sharps: “Sharps” refers to items that have sharp points or cutting edges capable of piercing or cutting human skin. Typical items in the laboratories are scalpels, needles, scissors, tweezers and pieces of broken glass or plastic. The risk of injury is obvious, but when contaminated with biological agents they create a greater hazard, so the use of sharps should be reduced to a minimum wherever possible. Where they are needed, they should be handled and disposed of carefully.

-----------------------------------------------------------
Sigue este Blog en Facebook y Twitter
-----------------------------------------------------------

#LIBRO: Integrando la Investigación Clínica en la Respuesta Epidémica: La Experiencia del #Ébola (INGLÉS)

Publication Info

342 pages | 6 x 9 
ISBNs: 

• Paperback: 978-0-309-45776-7
• Ebook: 978-0-309-45779-8

DOI: https://doi.org/10.17226/24739 

La epidemia de ébola de 2014-2015 en África occidental fue la epidemia de ébola más larga y mortal de la historia, con 28,616 casos y 11,310 muertes en Guinea, Liberia y Sierra Leona. El virus del Ébola se conoce desde 1976, cuando se identificaron dos brotes separados en la República Democrática del Congo (luego Zaire) y Sudán del Sur (entonces Sudán). Sin embargo, debido a que todos los brotes de ébola anteriores a los de África occidental en 2014-2015 fueron relativamente aislados y de corta duración, se sabía poco acerca de cómo manejar mejor a los pacientes para mejorar la supervivencia, y no había terapias o vacunas aprobadas. Cuando la Organización Mundial de Salud declaró que la epidemia de 2014-2015 era una emergencia de salud pública de interés internacional en agosto de 2014, varios equipos comenzaron a realizar ensayos clínicos formales en los países afectados por el ébola durante el brote.
Integrando la Investigación Clínica en la Respuesta Epidémica: La Experiencia del Ébola evalúa el valor de los ensayos clínicos realizados durante la epidemia 2014-2015 y hace recomendaciones sobre cómo podría mejorarse la realización de los ensayos en el contexto de una futura enfermedad infecciosa emergente o eventos reemergente internacionales.

REFERENCIA:

National Academies of Sciences, Engineering, and Medicine. 2017. Integrating Clinical Research into Epidemic Response: The Ebola Experience. Washington, DC: The National Academies Press. https://doi.org/10.17226/24739.

-----------------------------------------------------------
Sigue este Blog en Facebook y Twitter
-----------------------------------------------------------

Eliminación de contaminaciones microbianas de los textiles

La eliminación de contaminaciones microbianas de los textiles es un aspecto importante del lavado, aparte de la eliminación de manchas y suciedad de los textiles usados ​​y desgastados. Aunque el marco para el lavado institucional está bien regulado para garantizar la limpieza higiénica mediante el uso de altas temperaturas y agentes blanqueadores, hay varios puntos abiertos, especialmente en el lavado doméstico. En ambos casos, la eficiencia energética de los electrodomésticos es el principal impulsor de la innovación y ha resultado en una disminución general de las temperaturas de lavado que a su vez puede afectar la eficacia antimicrobiana del lavado. Por lo tanto, los diferentes factores que influyen en la entrada y eliminación de células microbianas en el proceso de lavado y los posibles efectos adversos de los contaminantes microbianos en la lavadora y en los textiles, así como las medidas adecuadas, se abordan en este artículo, centrándose en el área clínica pero también considerando el entorno doméstico, que cobrará importancia en el futuro, por ejemplo por el aumento de personas mayores y enfermas atendidas en el hogar.
-------------------------------

The elimination of microbial contaminations from textile is an important aspect of laundering apart from the removal of stains and dirt from used and worn textiles. Although the framework for institutional laundering is well regulated to ensure hygienic cleanliness via the use of e.g. high temperatures and bleaching agents, there are several open points, especially in domestic laundering. In both cases, energy efficiency of appliances is a main driver for innovation and has resulted in a general decrease in washing temperatures which in turn can impact the antimicrobial efficacy of laundering. Thus, the different factors influencing the input and removal of microbial cells in the laundering process and possible adverse effects of microbial contaminants in the washing machine and on the textiles as well as suitable counteractions are discussed in this article, focusing on the clinical area but also considering the domestic environment, which will gain importance in the future, e.g. by the increase of elderly and ill persons being cared for at home.

REFERENCE:

Bockmühl DP, Schages J, Rehberg L. Laundry and textile hygiene in healthcare and beyond. Microb Cell. 2019;6(7):299–306. Published 2019 Jul 1. doi:10.15698/mic2019.07.682

-----------------------------------------------------------
Sigue este Blog en Facebook y Twitter
-----------------------------------------------------------

Construyendo la capacidad de laboratorio para el diagnóstico de patógenos en Kenia

Desde 1979, múltiples programas de los CDC en Kenia han apoyado el desarrollo de experiencia en diagnóstico y capacidad de laboratorio en Kenia. En 2004, el programa de Detección Global de Enfermedades (DGD) de los CDC dentro de la División de Protección Global de la Salud en Kenia (DGHP-Kenia) inició una estrecha colaboración con el Instituto de Investigación Médica de Kenia (KEMRI) y desarrolló una asociación de laboratorio llamada Programa de Sistemas de Diagnóstico y Laboratorio (DLSP). DLSP se basó en los esfuerzos previos de los programas de malaria, virus de inmunodeficiencia humana (VIH) y tuberculosis (TB) y apoyó la expansión de la experiencia y capacidad de diagnóstico en KEMRI y el Ministerio de Salud. Primero, DLSP desarrolló capacidad de laboratorio para la vigilancia de enfermedades diarreicas, respiratorias, zoonóticas y febriles para comprender la carga etiológica de estas enfermedades comunes y apoyar decisiones basadas en evidencia sobre la introducción de vacunas y recomendaciones en Kenia. En segundo lugar, hemos evaluado e implementado nuevas tecnologías de diagnóstico como TaqMan Array Cards (TAC) para detectar patógenos emergentes o reemergentes y recientemente hemos agregado un secuenciador de próxima generación (NGS). En tercer lugar, DLSP brindó un rápido apoyo de diagnóstico de laboratorio para la investigación de brotes a Kenia y países regionales. Cuarto, DLSP ha estado ayudando al laboratorio nacional de salud pública de Kenia-Centro Nacional de Influenza y laboratorio de referencia de microbiología para obtener la certificación de la Organización Mundial de la Salud (OMS) y la acreditación ISO15189 respectivamente. Quinto, hemos apoyado el desarrollo del currículo de bioseguridad y bioseguridad para ayudar a los laboratorios de Kenia a manejar de manera segura y apropiada los patógenos infecciosos. Estos logros resaltan cómo, en colaboración con los programas existentes de los CDC que trabajan en VIH, tuberculosis y malaria, la Agenda de Seguridad de Salud Global puede mejorar significativamente la salud pública en Kenia y la región. Además, Kenia ofrece un ejemplo de cómo la ciencia de laboratorio puede ayudar a los países a detectar y controlar los brotes de enfermedades infecciosas y otras amenazas a la salud pública más rápidamente, mejorando así la seguridad sanitaria mundial.

REFERENCIA:

Hunsperger, Elizabeth et al. Building laboratory capacity to detect and characterize pathogens of public and global health security concern in Kenya. BMC Public Health vol. 19, Suppl 3 477. 10 May. 2019, doi:10.1186/s12889-019-6770-9

-----------------------------------------------------------
Sigue este Blog en Facebook y Twitter
-----------------------------------------------------------

#LIBRO: La biodefensa en la era de la biología sintética (INGLÉS)

Publication Info

188 pages | 8.5 x 11 
ISBNs: 

• Paperback: 978-0-309-46518-2
• Ebook: 978-0-309-46521-2

DOI: https://doi.org/10.17226/24890 

Los avances científicos en las últimas décadas han acelerado la capacidad de diseñar organismos existentes y crear potencialmente nuevos que no se encuentran en la naturaleza. La biología sintética, que colectivamente se refiere a conceptos, enfoques y herramientas que permiten la modificación o creación de organismos biológicos, se está llevando a cabo de manera abrumadora con fines beneficiosos que van desde reducir la carga de la enfermedad hasta mejorar los rendimientos agrícolas y remediar la contaminación. Aunque las contribuciones que la biología sintética puede hacer en estas y otras áreas son muy prometedoras, también es posible imaginar usos maliciosos que podrían amenazar a los ciudadanos estadounidenses y al personal militar. Tomar decisiones informadas sobre cómo abordar tales preocupaciones requiere una evaluación realista de las capacidades que podrían ser mal utilizadas.
La biodefensa en la era de la biología sintética explora y visualiza los posibles usos indebidos de la biología sintética. Este informe desarrolla un marco para guiar una evaluación de las preocupaciones de seguridad relacionadas con los avances en biología sintética, evalúa los niveles de preocupación garantizados para tales avances e identifica opciones que podrían ayudar a mitigar esas preocupaciones.

REFERENCE:
National Academies of Sciences, Engineering, and Medicine. 2018. Biodefense in the Age of Synthetic Biology. Washington, DC: The National Academies Press. https://doi.org/10.17226/24890.
-----------------------------------------------------------
Sigue este Blog en Facebook y Twitter
-----------------------------------------------------------