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lunes, 27 de marzo de 2017

Infección de felinos con influenza H5N1

Existen varios reportes de infecciones de felinos con influenza H5N1. Este virus fué capaz de infectar gatos domésticos, tigres, leopardos, y leones. En todos los casos los felinos se cree que se infectaron por el consumo de carne de aves crudas, y que estaban contaminadas con influenza, ingresando a través de la tráquea. En todos los casos, los felinos tuvieron problemas respiratorios, fiebre y murieron poco después. La confirmación de la infección se realizó mediante pruebas moleculares que identificaron la cepa de influenza con el que enfermaron. Los casos reportados de infección por influenza en gatos domésticos son mas comunes, pero los casos documentados de felinos en vida salvaje son raros.

Kuiken T, et al. Avian H5N1 influenza in cats. Science. 2004 Oct 8;306(5694):241.
Keawcharoen, Juthatip et al. “Avian Influenza H5N1 in Tigers and Leopards.” Emerging Infectious Diseases 10.12 (2004): 2189–2191.
Chen, Quanjiao et al. “First Documented Case of Avian Influenza (H5N1) Virus Infection in a Lion.” Emerging Microbes & Infections 5.12 (2016): e125–.
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martes, 21 de marzo de 2017

Convocatoria Trabajos Libres #SIBB17

Ya se encuentra abierta la convocatoria para el envío de resúmenes para el 9º Simposio de Bioseguridad y Biocustodia, que se llevará a cabo en el Laboratorio Estatal de Salud Pública de Michoacán (LESPM), de Junio 7 al 10, 2017 en la ciudad de Morelia, Michoacán. Para más detalles en relación al formato y forma de envío, revisar la siguiente página electrónica:

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lunes, 20 de marzo de 2017

Responsible life sciences research for global health security

Advances in life sciences research are inextricably linked to improvements in human, plant and animal health. Promotion of excellent, high-quality life sciences research that is conducted responsibly, safely and securely can foster global health security and contribute to economic development, evidence-informed policy making, public trust and confidence in science. Yet opportunities may also be accompanied by risks that need to be acknowledged and addressed. The risks under consideration in this guidance are those associated with accidents, with research that may pose unexpected risks and with the potential deliberate misuse of life sciences research. The opportunities offered by the life sciences are too important for governments and the scientific community (including individual researchers, laboratory managers, research institutions, professional associations, etc.) to leave the attendant risks unaddressed.
The purpose of this guidance is to inform about the risks posed by accidents or the potential deliberate misuse of life sciences research and to propose measures to minimize these risks within the context of promoting and harnessing the power of the life sciences to improve health for all people. Although the issues addressed in this document can potentially interest a quite large audience, the proposed measures and the selfassessment questionnaire are of a public health nature. Health researchers, laboratory managers and research institutions are therefore the primary audience of this guidance.

Responsible life sciences researchfor global health security. A guidance document
Publication details
Publication date: 2010
Languages: English
WHO reference number: WHO/HSE/GAR/BDP/2010.2
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lunes, 13 de marzo de 2017

Synthetic biology approaches to biological containment: pre-emptively tackling potential risks

Routes to biological containment
Biocontainment comprises any strategy applied to ensure that harmful organisms are confined to controlled laboratory conditions and not allowed to escape into the environment. Genetically engineered microorganisms (GEMs), regardless of the nature of the modification and how it was established, have potential human or ecological impact if accidentally leaked or voluntarily released into a natural setting. Although all evidence to date is that GEMs are unable to compete in the environment, the power of synthetic biology to rewrite life requires a pre-emptive strategy to tackle possible unknown risks. Physical containment barriers have proven effective but a number of strategies have been developed to further strengthen biocontainment. Research on complex genetic circuits, lethal genes, alternative nucleic acids, genome recoding and synthetic auxotrophies aim to design more effective routes towards biocontainment. Here, we describe recent advances in synthetic biology that contribute to the ongoing efforts to develop new and improved genetic, semantic, metabolic and mechanistic plans for the containment of GEMs.

Torres, Leticia et al. “Synthetic Biology Approaches to Biological Containment: Pre-Emptively Tackling Potential Risks.” Ed. Vitor B. Pinheiro. Essays in Biochemistry 60.4 (2016): 393–410. PMC. Web. 8 Feb. 2017.
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lunes, 6 de marzo de 2017

Does Zika virus infection affect mosquito response to repellents?

The World Health Organization (WHO) recommends that people travelling to or living in areas with Zika virus (ZIKV) outbreaks or epidemics adopt prophylactic measures to reduce or eliminate mosquito bites, including the use of insect repellents. It is, however, unknown whether repellents are effective against ZIKV-infected mosquitoes, in part because of the ethical concerns related to exposing a human subject’s arm to infected mosquitoes in the standard arm-in-cage assay. We used a previously developed, human subject-free behavioural assay, which mimics a human subject to evaluate the top two recommended insect repellents. Our measurements showed that DEET provided significantly higher protection than picaridin provided against noninfected, host-seeking females of the southern house mosquito, Culex quinquefasciatus, and the yellow fever mosquito, Aedes aegypti. When tested at lower doses, we observed a significant reduction in DEET-elicited protection against ZIKV-infected yellow fever mosquitoes from old and recent laboratory colonies. The reduction in protection is more likely associated with aging than the virus infection and could be compensated by applying a 5x higher dose of DEET. A substantial protection against ZIKV-infected and old noninfected mosquitoes was achieved with 5% DEET, which corresponds approximately to a 30% dose in the conventional arm-in-cage assays.
Leal WS, et al. Does Zika virus infection affect mosquito response to repellents? Sci Rep. 2017 Feb 16;7:42826.

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