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martes, 31 de marzo de 2015

7º Simposio Internacional de Bioseguridad y Biocustodia #SIBB15

Publicado el 17/Feb/2015

En su 7a. edición, el Simposio Internacional de Bioseguridad y Biocustodia 2015 (#SIBB15), la Asociación Mexicana de Bioseguridad A.C. en colaboración con el Instituto Nacional de Enfermedades Respiratorias se realizará del 3 al 6 de Junio de 2015. En este VII Simposio se presentan un programa de cursos presimposio, pláticas magistrales, mesas de discusión, seminarios y exposición comercial que congregarán a expertos e interesados de México y el extranjero.


¿Quién debe asistir?

Profesionales de la salud humana, ámbito agropecuario e industrial involucrados en temas de bioseguridad, biocontención, gestión de riesgos biológicos y biotecnológicos, involucrados en manejo de materiales biológico infecciosos. Este simposio de bioseguridad (SIBB) es una reunión especializada en el entrenamiento, análisis, discusión y planteamiento de propuestas alrededor de la seguridad biológica y los materiales biológico infecciosos en México y nuestro entorno. El SIBB es organizado por la Asociación Mexicana de Bioseguridad A.C. desde 2009. 

Por favor consulten toda la información en la Página del VII Simposio

CONSULTE EL PROGRAMA

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lunes, 30 de marzo de 2015

Curso nuevo: "Introducción a la biología sintética"

Realizamos algunas modificaciones al programa.
Por favor, visiten la página:
http://www.amexbio.wildapricot.org/Programa

Curso nuevo de 8 horas: "Introducción a la biología sintética" 
Ponentes: David Gillum,  Juan Maldonado Ortíz,  Irene Mendoza, de la Universidad Estatal de Arizona.
Miércoles 3 de Junio, 2015.
Registro en los próximos días

Descripción del curso
La biología sintética es una disciplina emergente en la interfaz entre la biología de sistemas, la ingeniería, la computación y la biología molecular clásica. El objetivo de esta disciplina es la construcción de sistemas biológicos nuevos y el establecimiento de principios para su diseño racional. Con esta nueva disciplina se han desarrollado diversas herramientas biotecnológicas, así como estrategias para corroborar principios de diseño de sistemas biológicos. También se han generado potentes aplicaciones biotecnológicas y biomédicas. El propósito de este curso es introducir a los participantes a esta nueva disciplina ya que el campo de la biología sintética desarollará un papel cada vez mayor en la investigación y la industria farmacéutica.

Objectivos del Curso
  • Tendrán conocimiento de los principios de la biología sintética y estarán familiarizados con el vocabulario común de la biología sintética.
  • Entenderán los conceptos fundamentales y las herramientas que se usan en la biología sintética.
  • Entenderán las tecnologías fundamentales de la biología sintética e identificarán los aspectos de la biotecnología que permiten la reprogramacción de sistemas naturales.
  • Entenderán las técnicas de laboratorio que se usan para las aplicaciones de biología sintética.
  • Entenderán las precauciones de bioseguridad y biocustodia que se deben tomar para trabajar con biología sintética.
  • Discutirán cuestiones éticas, ecológicas y del medio ambiente que se deben tomar en cuenta cuando se trabaja con biología sintética. También se discutiran las leyes que gobiernan a la biología sintética.
  • Entenderán y discutirán las aplicaciones de la biología sintética en el futuro.

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Annual European Biosafety Association (EBSA) Meeting 2015

18th Annual Meeting of the European Biosafety Association:

"Orchestrating a (bio)safe world"


21 - 22 April 2015: Pre-conference Courses
23 - 24 April 2015: Annual Conference 

at the Austria Vienna Center


=> INFORMATION <=

=> PROGRAM <=

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jueves, 26 de marzo de 2015

European do-it-yourself (DIY) biology: Beyond the hope, hype and horror

Fig. Kitchen-style equipment for
amateur biology experiments
The encounter of amateur science with synthetic biology has led to the formation of several amateur/do-it-yourself biology (DIYBio) groups worldwide. Although media outlets covered DIYBio events, most seemed only to highlight the hope, hype, and horror of what DIYBio would do in the future. Here, we analyze the European amateur biology movement to find out who they are, what they aim for and how they differ from US groups. We found that all groups are driven by a core leadership of (semi-)professional people who struggle with finding lab space and equipment. Regulations on genetic modification limit what groups can do. Differences between Europe and the US are found in the distinct regulatory environments and the European emphasis on bio-art. We conclude that DIYBio Europe has so far been a responsible and transparent citizen science movement with a solid user base that will continue to grow irrespective of media attention.

REFERENCE:
Seyfried G, Pei L, Schmidt M. European do-it-yourself (DIY) biology: Beyond the hope, hype and horror. Bioessays. 2014;36(6):548-551. doi:10.1002/bies.201300149.
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lunes, 23 de marzo de 2015

Intrinsic biocontainment: Multiplex genome safeguards combine transcriptional and recombinational control of essential yeast genes

The advance of biotechnology opens up greater possibilities of bioterror and bioerror. Here, we propose multiplexed safeguard switches rooted in the development of foundational genomic, regulatory, and metabolic technologies. Safeguard switches can be regulated by submicromolar small molecule(s) and combined in a modular fashion. The resulting safeguard strains show high fitness and low reversion rates. Moreover, two distinct classes of safeguard switches are orthogonal, providing a potential fail-safe mechanism. The safeguard technologies provide a practical and generic approach to containing engineered microbes within defined laboratory and/or industrial environments, and can in principle be used in the field as well.

REFERENCE:
Cai Y, Agmon N, Choi WJ, et al. Intrinsic biocontainment: Multiplex genome safeguards combine transcriptional and recombinational control of essential yeast genes. PNAS 2015;112(6):1803-1808.
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viernes, 20 de marzo de 2015

Negotiating the dynamics of uncomfortable knowledge: The case of dual use and synthetic biology

Institutions need to ignore some knowledge in order to function. This is “uncomfortable knowledge” because it undermines the ability of those institutions to pursue their goals (Rayner, 2012). We identify three bodies of knowledge that are relevant to understandings of the dual use threat posed by synthetic biology but are excluded from related policy discussions. We demonstrate how these “unknown knowns” constitute uncomfortable knowledge because they disrupt the simplified worldview that underpins contemporary discourse on the potential misuse of synthetic biology by malign actors. We describe how these inconvenient truths have been systematically ignored and argue that this is because they are perceived as a threat by organisations involved in the promotion of synthetic biology as well as by those involved in managing biosecurity risks. This has led to a situation where concerns about the biosecurity threat posed by synthetic biology are not only exaggerated, but are, more importantly, misplaced. This, in turn, means that related policies are misdirected and unlikely to have much impact. We focus on the dynamics of discussions about synthetic biology and dual use to demonstrate how the same “knowns” that are denied or dismissed as “unknown knowns” in certain circumstances are sometimes mobilised as “known knowns” by the same category of actors in a different context, when this serves to sustain the goals of the individuals and institutions involved. Based on our own experience, we argue that negotiating the dynamics of uncomfortable knowledge is a difficult, but necessary, component of meaningful transdisciplinary collaborations.
REFERENCE:
Marris C, Jefferson C, Lentzos F. Negotiating the dynamics of uncomfortable knowledge: The case of dual use and synthetic biology. Biosocieties. 2014;9(4):393-420. doi:10.1057/biosoc.2014.32.
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miércoles, 18 de marzo de 2015

Evolution of #Ebola Virus Disease, Liberia, Mid-2014

Figure 1. Counties in Liberia reporting Ebola virus
disease cases as of August 15, 2014.
Star indicates the capital city, Monrovia.
Over the span of a few weeks during July and August 2014, events in West Africa changed perceptions of Ebola virus disease (EVD) from an exotic tropical disease to a priority for global health security. We describe observations during that time of a field team from the Centers for Disease Control and Prevention and personnel of the Liberian Ministry of Health and Social Welfare. We outline the early epidemiology of EVD within Liberia, including the practical limitations on surveillance and the effect on the country’s health care system, such as infections among health care workers. During this time, priorities included strengthening EVD surveillance; establishing safe settings for EVD patient care (and considering alternative isolation and care models when Ebola Treatment Units were overwhelmed); improving infection control practices; establishing an incident management system; and working with Liberian airport authorities to implement EVD screening of departing passengers.
REFERENCE:
Arwady MA, et al. Evolution of Ebola virus disease from exotic infection to global health priority, Liberia, mid-2014. Emerg Infect Dis. 2015 Apr
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lunes, 16 de marzo de 2015

Prions - Not Your Immunologist’s Pathogen.

A colleague and fellow immunologist, we will call her “Anne,” lifts her index and middle fingers on each hand and bows them in “air quotes” as she says prion “immunology” during my student’s thesis committee meeting. Anne says she works on “malaria, a real pathogen that elicits a real immune response.” Now, I am pretty sure Anne believes prions exist, but does she have a point about the immune response they elicit? The answer may surprise you.
Prions are remarkable, enigmatic pathogens that are quite different than most disease-causing entities. According to the prion hypothesis, prions are infectious agents devoid of instructional nucleic acid [1]. They propagate themselves without a genetic code, instead enciphering their infectious nature structurally, within the protein conformation itself. Mounting evidence supports the prion hypothesis, including the generation of infectious prions from purified recombinant protein [2]. Soon after Prusiner coined the term “prion,” his and Charles Weissmann’s labs discovered that a cellular gene encodes the prion agent [3]. Strangely, though, Prusiner had already demonstrated that infectious prions did not include nucleic acid, suggesting that prions infect without transmitting the gene encoding them. So attention turned to the host, in which this gene also encodes a normal form of the agent, called cellular prion protein (PrPC), that was later shown to be absolutely required to generate both genetic and acquired prion diseases [4]. And so, all the armchair immunologists reading this article right now pause and say, “Wait a minute…” while Anne chimes in with “prion immunology.” Here we go.

REFERENCE:
Zabel MD, Avery AC (2015) Prions—Not Your Immunologist’s Pathogen. PLoS Pathog 11(2): e1004624. doi:10.1371/journal.ppat.1004624
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jueves, 12 de marzo de 2015

Guidance for Safe Handling of Human Remains of Ebola Patients in U.S.


NIOSH Releases New Ebola Guidance

Given the systems currently in place to identify people with Ebola virus disease (EVD), any Ebola-related deaths in the United States would likely occur within a hospital setting. The Ebola virus can be detected throughout the bodies of patients who die of the disease. Ebola can be transmitted in postmortem care settings by laceration and puncture with contaminated instruments used during postmortem care, through direct handling of human remains without recommended PPE, and through splashes of blood or other body fluids such as urine, saliva, feces, or vomit to unprotected mucosa such as eyes, nose, or mouth during postmortem care.

Page Summary 


  • Who this is for: Personnel who perform postmortem care in U.S. hospitals and mortuaries. 
  • What this is for: To protect against the postmortem spread of Ebola infection at the site of death, prior to transport, during transport, at the mortuary, and during final disposition of remains 
  • How to use: To guide staff in the safe handling of human remains that may contain Ebola virus by properly using personal protective equipment (PPE) and following decontamination measures at every step of the process. 
See CDC's Mortuary Guidance Job Aid [1 page] for more information on postmortem preparation in a hospital room. More information.

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miércoles, 11 de marzo de 2015

Ya se abrieron las inscripciones al 7º Simposio de #Bioseguridad #AMexBio

Ya se abrieron las inscripciones para 7º Simposio de Bioseguridad y Biocustodia 2015, organizado por la Asociación Mexicana de Bioseguridad A.C. Las inscripciones con descuentos son hasta el día 9 de Abril de 2015. Consulta el programa, y da click en cada uno de los cursos para inscribirte. Recuerda que la inscripción al Simposio es independiente de la inscripción a cada uno de los cursos.
INFORMES:
http://amexbio.wildapricot.org/SIBB

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