Ya se encuentra abierta la convocatoria para el envío de resúmenes para el 9º Simposio de Bioseguridad y Biocustodia, que se llevará a cabo en el Laboratorio Estatal de Salud Pública de Michoacán (LESPM), de Junio 7 al 10, 2017 en la ciudad de Morelia, Michoacán. Para más detalles en relación al formato y forma de envío, revisar la siguiente página electrónica: https://amexbio.wildapricot.org/TrabajosLibres
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Advances in life sciences research are inextricably linked to improvements in human, plant and animal health. Promotion of excellent, high-quality life sciences research that is conducted responsibly, safely and securely can foster global health security and contribute to economic development, evidence-informed policy making, public trust and confidence in science. Yet opportunities may also be accompanied by risks that need to be acknowledged and addressed. The risks under consideration in this guidance are those associated with accidents, with research that may pose unexpected risks and with the potential deliberate misuse of life sciences research. The opportunities offered by the life sciences are too important for governments and the scientific community (including individual researchers, laboratory managers, research institutions, professional associations, etc.) to leave the attendant risks unaddressed.
The purpose of this guidance is to inform about the risks posed by accidents or the potential deliberate misuse of life sciences research and to propose measures to minimize these risks within the context of promoting and harnessing the power of the life sciences to improve health for all people. Although the issues addressed in this document can potentially interest a quite large audience, the proposed measures and the selfassessment questionnaire are of a public health nature. Health researchers, laboratory managers and research institutions are therefore the primary audience of this guidance.
Biocontainment comprises any strategy applied to ensure that harmful organisms are confined to controlled laboratory conditions and not allowed to escape into the environment. Genetically engineered microorganisms (GEMs), regardless of the nature of the modification and how it was established, have potential human or ecological impact if accidentally leaked or voluntarily released into a natural setting. Although all evidence to date is that GEMs are unable to compete in the environment, the power of synthetic biology to rewrite life requires a pre-emptive strategy to tackle possible unknown risks. Physical containment barriers have proven effective but a number of strategies have been developed to further strengthen biocontainment. Research on complex genetic circuits, lethal genes, alternative nucleic acids, genome recoding and synthetic auxotrophies aim to design more effective routes towards biocontainment. Here, we describe recent advances in synthetic biology that contribute to the ongoing efforts to develop new and improved genetic, semantic, metabolic and mechanistic plans for the containment of GEMs.
The World Health Organization (WHO) recommends that people travelling to or living in areas with Zika virus (ZIKV) outbreaks or epidemics adopt prophylactic measures to reduce or eliminate mosquito bites, including the use of insect repellents. It is, however, unknown whether repellents are effective against ZIKV-infected mosquitoes, in part because of the ethical concerns related to exposing a human subject’s arm to infected mosquitoes in the standard arm-in-cage assay. We used a previously developed, human subject-free behavioural assay, which mimics a human subject to evaluate the top two recommended insect repellents. Our measurements showed that DEET provided significantly higher protection than picaridin provided against noninfected, host-seeking females of the southern house mosquito, Culex quinquefasciatus, and the yellow fever mosquito, Aedes aegypti. When tested at lower doses, we observed a significant reduction in DEET-elicited protection against ZIKV-infected yellow fever mosquitoes from old and recent laboratory colonies. The reduction in protection is more likely associated with aging than the virus infection and could be compensated by applying a 5x higher dose of DEET. A substantial protection against ZIKV-infected and old noninfected mosquitoes was achieved with 5% DEET, which corresponds approximately to a 30% dose in the conventional arm-in-cage assays.
Leal WS, et al. Does Zika virus infection affect mosquito response to repellents? Sci Rep. 2017 Feb 16;7:42826.
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La Secretaría del Trabajo y Previsión Social, en ejercicio de sus atribuciones de normalización, publicó en el Diario Oficial de la Federación de fecha 28 de abril de 2014, la Norma Oficial Mexicana NOM-010-STPS-2014, Agentes químicos contaminantes del ambiente laboral - Reconocimiento, evaluación y control, misma que tiene por objeto establecer los procesos y las medidas para la prevención de riesgos a la salud del personal ocupacionalmente expuesto a agentes químicos contaminantes del ambiente laboral.
Dicha Norma rige en todo el territorio nacional y aplica a todos los centros de trabajo donde existan agentes químicos contaminantes del ambiente laboral, es decir, sustancias o mezclas capaces de modificar las condiciones ambientales del centro de trabajo y que, por sus propiedades, concentración, nivel y tiempo de exposición o acción, pueden alterar la salud de los trabajadores.
Campylobacteriosis is the most prevalent bacterial foodborne gastroenteritis affecting humans in the European Union, and ranks second in the United States only behind salmonellosis. In Europe, there are about nine million cases of campylobacteriosis every year, making the disease a major public health issue. Human cases are mainly caused by the zoonotic pathogen Campylobacter jejuni. The main source of contamination is handling or consumption of poultry meat. Poultry constitutes the main reservoir of Campylobacter, substantial quantities of which are found in the intestines following rapid, intense colonization. Reducing Campylobacter levels in the poultry chain would decrease the incidence of human campylobacteriosis. As primary production is a crucial step in Campylobacter poultry contamination, controlling the infection at this level could impact the following links along the food chain (slaughter, retail and consumption). This review describes the control strategies implemented during the past few decades in primary poultry production, including the most recent studies. In fact, the implementation of biosecurity and hygiene measures is described, as well as the immune strategy with passive immunization and vaccination trials and the nutritional strategy with the administration of organic and fatty acids, essential oil and plant-derived compound, probiotics, bacteriocins and bacteriophages.
OBJECTIVES: The purpose of this study was to investigate the permeation of the low-volatile solvent limonene through different disposable, unlined, unsupported, nitrile exam whole gloves (blue, purple, sterling, and lavender, from Kimberly-Clark).
METHODS: This study utilized a moving and static dextrous robot hand as part of a novel dynamic permeation system that allowed sampling at specific times. Quantitation of limonene in samples was based on capillary gas chromatography-mass spectrometry and the internal standard method (4-bromophenol).
RESULTS: The average post-permeation thicknesses (before reconditioning) for all gloves for both the moving and static hand were more than 10% of the pre-permeation ones (P ≤ 0.05), although this was not so on reconditioning. The standardized breakthrough times and steady-state permeation periods were similar for the blue, purple, and sterling gloves. Both methods had similar sensitivity. The lavender glove showed a higher permeation rate (0.490 ± 0.031 μg/cm2/min) for the moving robotic hand compared to the non-moving hand (P ≤ 0.05), this being ascribed to a thickness threshold.
CONCLUSIONS: Permeation parameters for the static and dynamic robot hand models indicate that both methods have similar sensitivity in detecting the analyte during permeation and the blue, purple, and sterling gloves behave similarly during the permeation process whether moving or non-moving.
Bone-sawing procedures are routinely performed during veterinary and human autopsies and represent an important source for infectious aerosols. Here we investigate the generation of aerosols during bone-sawing procedures using 5 different saws regularly used in veterinary and human pathology. In particular, the electrical bone band saw produced vast amounts of aerosolized particles less than 5 µm in diameter, which spread rapidly throughout the entire autopsy hall, leading to an exposure of all personnel. Other sawing devices tested were a diamond-coated cut grinder, an oscillating saw, a reciprocating saw, and a hand bone saw. Although these saws, especially the handsaw, generated fewer aerosolized particles than the band saw, the level of exposure of the saw operator would still be of concern in cases where infectious material would require sawing. Contamination of the entire autopsy area was successfully prevented by the construction of a separately ventilated sawing cabin inside the existing autopsy room. Saw operators in this cabin, however, were exposed to even higher aerosol concentrations. Protection of saw operators was achieved by using a powered air-purifying respirator. In conclusion, our results demonstrate that all bone-sawing procedures applied in veterinary and human pathology can generate aerosols that are of concern for the health of autopsy personnel. To reduce the risk of aerosol infections from bone-sawing procedures, efficient and properly designed ventilation systems to limit the spread of aerosols and appropriate personal protective equipment against aerosols for exposed personnel should be implemented.