The highly pathogenic Marburg virus (MARV) is a member of the Filoviridae family and belongs to the group of nonsegmented negative-strand RNA viruses. Reverse genetics systems established for MARV have been used to study various aspects of the viral replication cycle, analyze host responses, image viral infection, and screen for antivirals. This article provides an overview of the currently established MARV reverse genetic systems based on minigenomes, infectious virus-like particles and full-length clones, and the research that has been conducted using these systems.
Keywords: Marburg virus; Ebola virus; filoviruses; nonsegmented negative-sense RNA viruses; reverse genetics system; minigenome; full-length clones; virus-like particles; virus rescue; biosafety level 4
REFERENCE:
Schmidt KM, Mühlberger E.
Marburg Virus Reverse Genetics Systems. Viruses. 2016 Jun 22;8(6).
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