viernes, 18 de abril de 2014

Emergence of Zaire Ebola Virus Disease in Guinea — Preliminary Report

Map of Guinea Showing Initial Locations
of the Outbreak of Ebola Virus Disease
In March 2014, the World Health Organization was notified of an outbreak of a communicable disease characterized by fever, severe diarrhea, vomiting, and a high fatality rate in Guinea. Virologic investigation identified Zaire ebolavirus (EBOV) as the causative agent. Full-length genome sequencing and phylogenetic analysis showed that EBOV from Guinea forms a separate clade in relationship to the known EBOV strains from the Democratic Republic of Congo and Gabon. Epidemiologic investigation linked the laboratory-confirmed cases with the presumed first fatality of the outbreak in December 2013. This study demonstrates the emergence of a new EBOV strain in Guinea.
Baize S. et al. Emergence of Zaire Ebola Virus Disease in Guinea — Preliminary Report. NEJM 2014, April 16, 2014DOI: 10.1056/NEJMoa1404505
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