We have read with interest the recent paper by Kang, et al (2017), addressing clinical and ethical issues related to the safe and responsible use of CRISPR/Cas. The authors provide a number of important considerations about the current capabilities offered by this novel gene-editing tool, including germ line editing in embryos, and potential diverse uses in adult human applications. The authors posit that the tool in of itself does not represent a threat, and that periodic assessment will ensure its responsible use. We agree, but with caveat: namely, that any tool that imparts great capability also involves at least some risk, if not threat, that the power conferred by such capacity can be used to leverage or evoke a variety of ends. This deviation of intent is a principal concern of dual-use research and its applications.
REFERENCE:
DiEuliis, Diane, and James Giordano.
Gene editing using CRISPR/Cas9: implications for dual-use and biosecurity. Protein & cell vol. 9,3 (2018): 239-240. doi:10.1007/s13238-017-0493-4
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